After a virus turns most people into zombies, the world's surviving humans remain locked in an ongoing battle against the hungry undead. Four survivors Tallahassee (Woody Harrelson) and his cohorts Columbus (Jesse Eisenberg), Wichita (Emma Stone) and Little Rock (Abigail Breslin) abide by a list of survival rules and zombie-killing strategies as they make their way toward a rumored safe haven in Los Angeles.