Manuela (Cecilia Roth) works in a Madrid hospital. One night she takes her teenaged son Esteban to see a performance of A Streetcar Named Desire, with tragic results. Grief-stricken, she travels to Barcelona to look for Esteban’s father, now a transsexual prostitute named Lola (Toni Canto). She runs into another transsexual friend, Agrado (Antonia San Juan), and a pregnant young nun named Sister Rosa (Penélope Cruz). Each woman will provide comfort to one another in this deeply felt portrait of sisterhood and compassion. The film won several major international awards, including an Oscar for Best Foreign Language Film.